025 Neurofibromatosis type 1 related breast cancer: Increased risk, exceptional histopathological characteristics and poor survival
نویسندگان
چکیده
منابع مشابه
Neurofibromatosis type 1 and male breast cancer: emerging risk factor?
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by the appearance of cafe au lait spots, neurofibromas and Lisch nodules. There is an established link between NF1 and the development of breast cancer in women; however, due to the rarity of both NF1 and male breast cancer, the same link has yet to be elucidated in men. The concurrent presentation of NF1 and male br...
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Neurofibromatosis type 1 (NF1) is an autosomal dominant condition caused by mutation/deletion of the NF1 gene. The gene product, neurofibromin, is a tumor suppressor which represses the activity of the Ras oncogene. Central nervous system (CNS) tumors have long been associated with NF1, but their association with several other malignancies has been demonstrated. In this review, we summarize the...
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Neurofibromatosis type 1 (NF1) is autosomal dominant and it is the most common hereditary disease. This case report is about a woman and her daughter. Both of them are NF1 and mother also has metachronous bilateral breast carcinoma. We analyzed expressions of 84 genes related with DNA Repair by Real Time PCR (AB Applied Biosystem 7000 Sequence Detection System; Thermo Fisher, Foster City, CA, U...
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ownloade kground: Matriptase plays a role in carcinogenesis, but the role of its genetic variation or that of the cyte growth factor activator inhibitor-1 (HAI-1) has not been evaluated. This study aimed to examine netic variation of matriptase (ST14 gene) and HAI-1 (SPINT1 gene) in breast cancer risk and prognosis, ess matriptase and HAI-1 gene and protein expression in breast tumors, and to i...
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Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients. M...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.042